Following is a list of co-curricular activities offered at Prep, along with their moderators:
| Activity | Moderator |
|---|---|
| Academic Bowl | Ms. Manye Otu & Ms. Jan Merski |
| Adventure Club | Mr. Greg Morrissey, ’08 |
| Aerospace Club | Ms. Manye Otu |
| Anime Club | Fr. Bob O’Hare, S.J. |
| Art Club/MarARTer | Ms. Megan Klim, P’16 & Mr. Patrick McCoy |
| Asian Society | Mr. Pat McGovern, ’99 |
| Band | Mr. Steve Caslowitz |
| Baseball Club | Mr. Carlos Tabora, ’87 & Mr. Pat Laguerre |
| Breaking Barriers | Mr. Jerry Campbell-Clark & Mr. Michael Prescia |
| Business Club | Ms. Kaitlyn Giroux |
| Celtic Club | Ms. Kitty McNally & Ms. Mary Anne McElroy |
| Charity Club | Mr. John Dougherty |
| Chess Club | Mr. Charles Coccaro |
| Classics Society | Mr. David Burokas, ’85 & Mr. David Caulfield, ’77 |
| Classical Performance Club | Mr. Steve Caslowitz |
| ConLang Club | Mr. David Burokas, ’85 |
| Culinary Club | Ms. Erin Stark & Mr. Michael Fletcher, P’21 |
| Cultural Game Club | Mr. Pat McGovern, ’99 |
| Diversity Board | Ms. Dalma Santana & Ms. Sarah Morissette |
| Dramatics Club | Mr. Adam Bouley |
| Dungeons & Dragons | Mr. Nick Dawybida, ’15 |
| Ebony Club | Mrs. Phadadria Randall |
| Economics Club (Fed & Euro Challenge) | Mr. Anthony Keating, ’78, P’10 |
| Engineering Club | Mrs. Donna Saulys & Mr. Nathan Riley |
| Environmental Club | Ms. Carmela Schlitzer |
| ESports Team | Mr. Michael Murcia, ’08 |
| Fed & Euro Challenge | Mr. Anthony Keating, ’78, P’10 |
| Feminism is for Everybody! | Ms. Mary Durante & Ms. Susan Woolever |
| Film Club | Ms. Sky Friendlander & Mr. Peter Geary, ’05 |
| Forensics Team | Mr. Joe Madonna & Mr. Dan Lembo, ’04 |
| French Club | Mr. Remi Pastorek |
| German Club | Mrs. Elisabeth Oberhollenzer & Mr. Sal Veniero, ’05 |
| Hebrew Club | Dr. Jeff Hartling & Ms. Sky Friedlander |
| Historical Conversations Club | Mr. Anthony Verdi, ’95 |
| Intramurals | Mr. Ryan O’Flaherty |
| Italian Club | Ms. Rosalie Romano |
| Law Society | Mr. Anthony Keating, ’78, P’10 |
| Library Advisory Board | Ms. Sky Friedlander & Mrs. Lili Hermeline |
| Literama | Ms. Alice McNally & Ms. Kaitlyn Giroux |
| Magic Club | Mr. Nathan Riley |
| Marauder Nation | Mr. Mike Murcia, ’08 |
| Math Club | Ms. Molly Molino & Mr. Jerry Campbell |
| Medical Club | Ms. Jan Merski & Mr. Kevin Kuhl, ’14 |
| Model UN | Ms. Mary Anne McElroy |
| Petrean | Ms. Kaitlyn Giroux |
| Petroc | Mr. Pete Geary, ’05 |
| Philosophy, Politics & Economics | Mr. Michael Allocca |
| Prep Soles & Fabrics | Mr. Michael Prescia |
| Progressive Society | Mr. Joe Giglio, ’87 |
| Robotics Team | Fr. Bob O’Hare, S.J. |
| Spanish Club | Ms. Aymee Torres & Ms. Miryam DeChiaro |
| SPPAC (Performing Arts Club) | Fr. John Mullin, S.J. & Ms. Trish Fitzpatrick, P’07,’16 |
| Spring Musical | Mr. Adam Bouley, Ms. Emily Fencik & Ms. Dalma Santana |
| Stage Crew | Mr. Rocko Tejada |
| Stock Market Club | Ms. Ella Glazer |
| Student Council | Ms. Catie Eppler & Mr. Michael Murcia, ’08 |
| Super Smash Brothers Club | Ms. Susan Woolever |
| TV Studio | Mr. Aashish Andrew, ’17 |
| Video Game Club | Fr. Bob O’Hare, S.J. |
| Vox | Ms. Emily Fencik |
| Winter Drama | Mr. Adam Bouley & Mr. Nick Dawybida |
| Yoga Club | Ms. Jessica Nordstrom |