Following is a list of co-curricular activities offered at Prep, along with their moderators:
| Activity | Moderator |
|---|---|
| Academic Bowl | Ms. Catie Eppler & Mr. Will Reese |
| Adventure Club | Mr. Greg Morrissey, ’08 |
| Anime Club | Fr. Bob O’Hare, S.J. |
| Art Club/MarARTer | Ms. Megan Klim, P’16 & Mr. Patrick McCoy |
| Asian Society | Mr. Pat McGovern, ’99 |
| Aviation Club | Mr. Anthony Keating, ’78, P’10 |
| Band | Mr. Steve Caslowitz |
| Baseball Club | Mr. Carlos Tabora, ’87 |
| Breaking Barriers | Mr. Joe Giglio, ’87 & Mr. Jerry Campbell-Clark |
| Celtic Club | Ms. Kitty McNally & Ms. Mary Anne McElroy |
| Chess Club | Mr. Charles Coccaro |
| Coding Club | Dr. Michael Holt, ’99 |
| Culinary Club | Ms. Erin Stark & Mr. Michael Fletcher, ’21 |
| Debate Club | Mr. Peter Welch |
| Diversity Board | Ms. Belkise Dallam & Ms. Sarah Morissette |
| Dramatics Club | Mr. Adam Bouley |
| Dungeons & Dragons | Mr. Will Reese |
| Ebony Club | Mr. Jim Dondero, ’66, P’00 |
| Economics Club | Mr. Anthony Keating, ’78, P’10 & Mr. Casey Quinn |
| Engineering Club | Dr. Michael Holt, ’99 |
| Environmental Club | Ms. Carmela Schlitzer |
| Fed & Euro Challenge | Mr. Anthony Keating, ’78, P’10 & Mr. Casey Quinn |
| Feminism is for Everybody | Ms. Mary Durante |
| French Club | Mr. Remi Pastorek |
| French Exchange | Mr. Remi Pastorek |
| Game of Thrones Club | Fr. Bob O’Hare, S.J. |
| German Club | Mr. Sal Veniero, ’05 |
| Hebrew Club | Dr. Jeff Hartling |
| History Club | |
| Intramurals | Mr. Ryan O’Flaherty |
| Italian Club | Ms. Rosalie Romano |
| Italian Exchange | Ms. Rosalie Romano |
| Law Society | Mr. Anthony Keating, ’78, P’10 |
| League of Legends Club | Mr. Carlos Tabora, ’87 |
| Marauder Nation | Mr. Mike Murcia, ’08 |
| Math Club | Mr. Jerry Campbell-Clark |
| Medical Club | Ms. Jan Merski & Mr. Kevin Kuhl, ’14 |
| Model UN | Mr. Will Reese |
| National Honor Society | Ms. Jessica Nordstrom & Ms. Grace Morris |
| Petrean | Mr. James Maglione, ’15 |
| Petroc | Mr. Pete Geary, ’05 |
| Prep Connection (Ignatian Scholars) | |
| Prep Soles | Ms. Belkise Dallam |
| Prom | Ms. Janice Martineau Ms. Diane Casazza, P’95,’97 |
| Psychology Club | Mr. Nathan Riley |
| Robotics Team | Fr. Bob O’Hare, S.J. |
| Rock & Blues Club | Mr. Steve Caslowitz |
| Liturgical Coordinator | Mr. Kieran Halloran, S.J. |
| Science National Honors Society | Mr. Tom Comey |
| Soccer Club | Ms. Caroline Hutchinson |
| Spanish Club | Ms. Aymee Torres & Ms. Miryam DeChiaro |
| Spanish Honor Society | Ms. Aymee Torres |
| SPPAC (Performing Arts Club) | Fr. John Mullin, S.J. & Ms. Trish Fitzpatrick, P’07,’16 |
| Spring Musical | Mr. Adam Bouley & Ms. Emily Fencik |
| Spring Musical – Producer | Ms. Dalma Santana |
| Stage Crew | Mr. Rocko Tejada |
| Stock Market Club | Ms. Ella Glazer |
| Student Council | Ms. Catie Eppler |
| Super Smash Brothers Club | Mr. Casey Quinn |
| TV Studio | Mr. James Maglione, ’15 & Mr. Anthony Locricchio, ’96 |
| Video Game Club | Fr. Bob O’Hare, S.J. |
| Vox | Ms. Emily Fencik |
| Winter Drama | Mr. Jim Dondero, ’66, P’00 |
| Yoga Club | Ms. Jessica Nordstrom & Dr. Natalie Williams |